The SaferWorldbyDesign Blog

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Driving Safe and Sustainable Innovation: Our Role in the SSbD4CheM Project

We are a contributing partner (Edelweiss Connect) to the SSbD4CheM project, an EU-funded initiative (HE) focused on material development in the textile, automotive, and cosmetics industries.

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SaferWorldbyDesign to release SaferSkin Version 2.0

At SaferWorldbyDesign our purpose is to make the assurance of product safety simpler and more efficient. Our journey began with a vision: to streamline safer design solutions, unburdened by the complexities of traditional methods.

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Collaborative Approaches: Addressing Next-Generation Risk Assessment and Safer by Design Challenges

Reflecting on the SaferWorldbyDesign: Safe and Sustainable by Design Networking Event held in Basel on August 22, 2023

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XtalPi and Edelweiss Connect Unite for AI-Enhanced Safety Assessment of Skincare Products

Today, XtalPi, a pioneering technology platform powered by Artificial Intelligence (AI) and robotics; and Edelweiss Connect (EwC), a Swiss-headquartered business focusing on next-generation product design and risk assessment solutions, announced a strategic partnership.

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The WC12 Conference Kicks Off in the Scenic Niagara Falls

If you are at WC12 in Niagara Falls please consider coming by the RISK-HUNT3R booth #38 where we are representing the ASPIS cluster of risk assessment projects (RISK-HUNT3R, ONTOX, PrecisionTox) and business collaborations aiming towards a SaferWorldbyDesign.

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Safe and Sustainable Networking Event

Safe and Sustainable by Design principles support the intelligent holistic design of products in which the human safety, environmental, life cycle impact and socio-economic sustainability factors are assessed. During this networking event we will discuss these principles and how we can proceed to implement them into practice. You can join us online or on-site. See you! Blog published on:

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SaferWorldbyDesign: Nature Restoration Law

We can feel positive today from yesterday’s vote in Europe on approving the Nature Restoration Law! We can look forward to both enjoying our outdoors and working on a smarter evidence-based future suite of products based on Safer- and Sustainable- byDesign principles. Let’s take a good walk and reflection on that together, mobilizing our resources for the journey ahead!

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SaferWorldbyDesign: Interactive Tools for Toxicogenomic Data Visualization

Here we highlight our contributions in facilitating data analysis and interpretation through easily accessible online notebooks. These notebooks offer valuable insights into prominent datasets: TempOSeq data generated within the EU-ToxRisk project, the DrugMatrix public dataset, and the TG-GATES public dataset.

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SaferWorldbyDesign: Modernization of Cosmetics Regulation Act of 2022 (MoCRA)

On December 29, 2022, President Joe Biden signed into law the Consolidated Appropriations Act, of 2023, which includes the Modernization of Cosmetics Regulation Act of 2022 (MoCRA).

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Data Science at SaferWorldbyDesign

SaferWorldbyDesign's expertise in data science combines technical expertise with strategic thinking, identifying key data sources to analyze and interpret the data and developing predictive models to mitigate potential chemical risks.

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SaferWorldbyDesign: 2023 SOT Annual Meeting & ToxExpo in Nashville

SaferWorldbyDesign - We will be participating in the Society of Toxicology (SOT) Annual Meeting and ToxExpo in Nashville!

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FDA Modernization Act 2.0 becomes law

Recently, the FDA Modernization Act 2.0 became law in the US, and crucially included a provision that ends the requirement of animal testing for new drugs.

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SafeDose releases ToxCalc!

ToxCalc! is a website purpose-built for toxicologists and other scientific professionals to help us do routine calculations.

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TEAM mastery joins SaferWorldbyDesign

Born in 2008 as a dedicated REACH consulting company, TEAM mastery now provides a range of services in Chemical Regulatory Affairs.

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How can Knowledge Graphs improve research in safety and risk assessment?

The term Knowledge Graph describes a new type of database technology that is applied to store data about a specific domain and to query the database with questions in natural language.

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Interested in using a Next Generation Risk Assessment Solution?

RISK-HUNT3R, short for “RISK assessment of chemicals integrating HUman centric Next generation Testing strategies promoting the 3Rs"

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SWBD Provider SenzaGen obtains OECD approval for GARD®skin

SenzaGen today announced that the Company has obtained approval from the OECD for GARD®skin as a test guideline for non-animal skin sensitization.

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SaferWorldbyDesign to provide services on Scientist.com and Science Exchange

We are proud to announce that the catalog of SaferWorldbyDesign products and services is now available through both the Science Exchange and Scientist.com networks.

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SaferWorldbyDesign Internship

This internship program is organised by Edelweiss Connect, GmbH, and SaferWorldbyDesign partners. Internships will run for six months with an emphasis on virtual work. Opportunities to visit and be hosted by SaferWorldbyDesign partners will also be considered.

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How to Foster ‘New Approach Methodology’ Toxicologists

The need to reduce, refine and replace animal experimentation has led to a boom in the establishment of new approach methodologies (NAMs). This promising trend brings the hope that the replacement of animals by using NAMs will become increasingly accepted by regulators, included in legislation, and consequently more often implemented by industry.

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Data analysis and visualization

Reliable analysis and consumption of data should be based on a foundation of sound data preparation, well-prepared metadata, data processing protocols, and reliable exposure of data through interfaces to end-user applications for data analysis, risk, and safety assessment.

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Case Studies in Skin Sensitization Assessment using OECD Guidance

Skin sensitization assessments for chemicals, cosmetics, and many pharmaceuticals are required by regulatory bodies for hazard assessment and approval. In June 2021, the Organization for Economic Co-operation and Development (OECD) published the new guideline (TG 497) for skin sensitization.

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JRC Data Visualization: Extrapolating from acute to chronic toxicity in vitro

An important question that was addressed within the EU-ToxRisk project relates to the extrapolation from acute to chronic effects of toxicants.

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Why choose the HepaRG™ cell model for NAFLD investigation?

Nonalcoholic fatty liver disease (NAFLD), the most common cause of chronic liver disease worldwide, is rapidly becoming the predominant cause of end-stage liver disease and a leading indication for liver transplantation.

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SaferWorldbyDesign: Trusted reproducible evidence supporting data-driven decisions

This blog post presents a collection of perspectives that elaborate our vision of reliable and reproducible science supporting product and risk assessment as presented by us this year at the Precision Health conference co-organized by MCBIOS and MAQC.

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Evaluating the skin sensitisation potential of a squaric acid

The SaferSkin™ Sensitization application implements three well-adopted defined approaches to perform an integrated analysis of the OECD-approved in vitro tests (DPRA, KeratinoSens™, h-CLAT) for assessment of skin sensitisation potential.

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OECD acceptance of Test Guideline 497 (TG 497)

The recent OECD acceptance of TG 497 for defined approaches for skin sensitization marks an important milestone.

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Provision of HepaRG™ on SaferWorldbyDesign

HepaRG™ has been manufactured and distributed for many years by Biopredic International, now part of Wepredic. We realized in recent years the increasing need for the development of HepaRG™ infrastructure and services to keep up with the increasing requirements of the HepaRG™ research community and requests from our customers.

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Dynamic gene expression profiling of the HepaRG™ cell line

A better molecular characterization of a cell line is a prerequisite for well-planned, educated, and targeted experimentation.

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Working as a Community on Data Integrity from Research through to Practice

An important commitment we are making is to ensure data integrity across the journey from research to practice, from case study work to service execution, from study planning through data generation to downstream consumption.

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High-throughput prediction of human organ toxicity

This innovative method (Su et al. 2016) was awarded with the Lush Science Price 2016 and combines cell-based assays with bioinformatics. The method predicts specifically toxicity to renal proximal tubular cells, which are one of the main targets for chemical-induced toxicity in the kidney.

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HepaRG™ ability to predict drug-cholestatic liability

Drug-induced liver injury (DILI) accounts for more than 50% of acute liver failure and constitutes therefore a major concern for the pharmaceutical industry in drug pre-and post-marketing scenarios.

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HepaRG™ goes digital

For many years HepaRG™ has provided a valuable liver cell line for research applications.

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SaferWorldbyDesign COVID-19 Data Initiative

Data is the gold of scientific prospecting, whether supporting research publications in academia or product development in industry.

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Launch of the EU-ToxRisk Commercial Platform

The EU-ToxRisk Commercialisation Platform was launched at the EU-ToxRisk Stakeholder meeting in Egmond, the Netherlands on 12 February.

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Integrated Approaches to solving Skin Safety Assessment problems

Skin safety is one of the most important goals of the consumer products industry.

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SBX’s Taxila™ adds more power to SaferWorldbyDesign

Taxila™ is a platform that aggregates the tons of data produced every day in natural text and converts it to actionable insights.

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Why Biopredic and Eurosafe join SaferWorldbyDesign

Dr. Christophe Chesné, the founder and CEO of Biopredic International and Eurosafe, explains why his two companies are founding partners of SaferWorldbyDesign.

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Making AI available to companies, large and small

Co-founder and CEO Tom Bell explains why Vertex Laboratories is a founding member of SaferWorldbyDesign.