3D InSight™ Human Liver Microtissues

3D InSight™ Human Liver Microtissues are prequalified, long-lived liver models designed for drug safety and efficacy testing, and the study of healthy and diseased liver function. Composed of the primary human liver cells necessary for core liver functions, these microtissues are delivered assay-ready, in a lab-automation-friendly plate format ideal for screening. Pre-validated and standardized, 3D InSight™ Human Liver Microtissues have been thoroughly characterized on a functional, transcriptomic, and proteomic level. This model represents a functional and physiologically relevant in vitro liver model that maintains stable function for more than 5 weeks in culture and is therefore well suited for a broad range of liver research applications, such as DILI (drug induced liver injury) prediction.

3D InSight™ Human Liver Microtissues
A physiologically relevant, functionally active human liver model. 3D InSightTM Human Liver Microtissues facilitate the study of liver function and response to (1) compound exposure by accurately recapitulating key liver functions typically compromised by disease or toxicity, including (2) bile acid secretion, (3) mitochondrial function and oxygen consumption rate (OCR), (4) inflammatory cytokine response, and (5) Cytochrome P450 activity.