3D InSight™ Human Liver Microtissues are prequalified, long-lived liver models designed for drug safety and efficacy testing, and the study of healthy and diseased liver function. Composed of the primary human liver cells necessary for core liver functions, these microtissues are delivered assay-ready, in a lab-automation-friendly plate format ideal for screening.
Transmembrane Transport Proteins (TMTs) control nutrient uptake, ion transport, and drug transport across biological membranes. Predicting substrate and inhibition profiles of small molecules towards these transporters helps medicinal chemists to prioritize compounds in an early phase of the drug development process and guide toxicologists in the safety assessment of candidate compounds.
HepG2 BAC-GFP platform
The HepG2 BAC-GFP chemical safety testing platform consists of a panel of >50 human reporter liver cell lines. In each of these stable cell lines, a specific biomarker of a stress pathway is tagged with a fluorophore.
Silensomes™ are human pooled liver microsomes in which cytochromes P450 (CYP) enzymes have been chemically knocked down, one per one. Silensomes™ is a unique solution for a direct quantitation of the fm (f for fraction, m for metabolized). Fm is a simple expression of the contribution of each CYP in drug metabolism of a test compound.