Undifferentiated HepaRG™ cells

HepaRG® cells have the unique properties of maintaining significant levels of hepatocyte functions, of being CYP450 inducible and supporting the complete replicative cycle of HBV. Catalog numbers HPR101 and HPR109 corresponds to a frozen vial of undifferentiated HepaRG® cells at passages P12 and P17. Available only after a license agreement made with Biopredic International (for profit customers) or under a MTA made with Inserm (for non profit customers).
Gripon P. et al. Proc. Natl. Acad. Sci. 99, 15655-15660, 2002.

HepaRG™ is a patented cell line (PCT/FR02/02391 of July 8, 2002) licensed to the company BIOPREDIC. For the benefit of the scientific community, the HepaRG™ cell line is available to academic researchers performing research projects not funded by the industry. Access is granted under a MTA that is standard and non-negotiable due to the specific context of patent protection and rights granted to BIOPREDIC. BIOPREDIC will manage the shipment of cells to the recipient and charge a minimal cost recovery fee to compensate for the preparation/shipment costs.

Instructions to receive the HepaRG™ cell line:

  1. Contact Mrs Agnes LAQUERBE ( and inform one of the inventors of the cell line of your willingness to perform research with HepaRG : Christiane Guillouzo ( or Philippe Gripon ( or Christian Trepo (
  2. Fill-in the MTA, have an authorized representative execute it in two (2) hard copies
  3. Send the executed copies by postmail to
    7, rue Watt
    75013 Paris – France
  4. Upon reception of a fully-executed copy by email ( Biopredic will then ship the cells

Material Transfer Agreement (MTA)

HepaRG® Propagation and Use Sublicense Agreement

  • P17
  • P12