SaferWorldbyDesign: Interactive Tools for Toxicogenomic Data Visualization
Here we highlight our contributions in facilitating data analysis and interpretation through easily accessible online notebooks. These notebooks offer valuable insights into prominent datasets: TempOSeq data generated within the EU-ToxRisk project, the DrugMatrix public dataset, and the TG-GATES public dataset.
Visualizing TempOSeq Data from the EU-ToxRisk Project
We developed an interactive Observable notebook dedicated to visualizing results from TempOSeq studies. The TempOSeq technology, utilized within the EU-ToxRisk project, allows for the simultaneous measurement of gene expression changes induced by different chemicals. With the provided notebook (accessible via this link), researchers gain access to visually appealing and informative representations of TempOSeq data. This tool enables the exploration and interpretation of gene expression patterns, supporting the identification of potential toxicological mechanisms and the development of predictive models.
Exploring the DrugMatrix Public Dataset
The DrugMatrix database contains comprehensive toxicogenomic data derived from drug exposure studies across various tissues and species. By leveraging the notebook (accessible via this link), researchers can easily navigate and visualize the extensive DrugMatrix dataset. This invaluable resource assists in identifying gene expression signatures associated with specific drugs, facilitating the prediction of adverse effects and aiding in the prioritization of safer alternatives.
Insights from the TG-GATES Public Dataset
To empower researchers, we provide a notebook dedicated to the analysis of the TG-GATES public dataset. TG-GATES is a toxicogenomics database encompassing gene expression profiles from various toxicant treatments in rat liver. Researchers can utilize the SaferWorldbyDesign Observable notebook (accessible via this link) to explore and visualize the TG-GATES dataset, uncovering valuable information about gene expression changes induced by different chemicals. This facilitates the identification of toxicological signatures and enhances our understanding of chemical-induced liver toxicity.