SaferWorldbyDesign Neurotoxicity

Neurotoxicity

The use of human pluripotent stem cells offers the opportunity to investigate the potential effects of xenobiotics on the nervous central system during the early stage of development of embryos or in later life stages. During research and development, early information on the neurotoxicity or developmental toxicity of chemicals can guide the selection of the process for candidate products.

In vitro Developmental Neurotoxicity

In vitro safety testing and in vitro efficacy testing

The use of human pluripotent stem cells offers the opportunity to investigate the potential effects of xenobiotics on the nervous central system during the early stage of development of the embryos or in later life stages. During research and development, early information on neurotoxicity or developmental toxicity of chemicals can guide the selection of the process for candidate products.

For the assessment of pesticides or drugs, in vitro safety testing is particularly useful for the elucidation of the mode of action.

iPSC neurosphere-based toxicity assays

2D monolayer- and 3D neurosphere-based toxicity assays

hiPSC-derived 21-day old neural cultures provided by BioTalentum contain developing neurons and astroglia precursors, while TD42 cultures contain more mature neurons, differentiated astrocytes, where synapses of the neurons are physically built up, and spontaneous firing activity is detectable.