Indre Piragyte-Langa Oliva
SSBD Basel 2024 Speakers - Indre Piragyte-Langa Oliva
Dr. Indre Piragyte-Langa Oliva is an expert in molecular biology and excels in genetic regulation and CRISPR-Cas9 technology, enhancing drug screening processes. She has specialized in hematopoietic development and COVID-19 treatment investigations using in vivo and in vitro models. She has 15 years of experience in scientific projects including data management and analysis and now takes a senior scientist role at Edelweiss Connect GmbH.
Hazard Characterisation using New Approach Methods
Safe and Sustainable by Design (SSbD) framework is an innovative strategy that proactively incorporates safety and sustainability into the product development process. By incorporating these concepts from the start of design, SSbD establishes a new standard for reducing environmental impact and protecting human health, which is critical as the chemical and materials industries grow. The increasing growth and variety of businesses that explore alternatives for currently circulating materials that might not reach sustainability standards required by the society necessitates an evolution in hazard characterisation techniques as well. Traditional methodologies frequently rely on substantial animal testing, which poses ethical concerns while also potentially failing to accurately predict real-world human and environmental interactions. In response, this session proposes New Approach Methods (NAMs), transformative tools that use cutting-edge scientific techniques to perform more accurate, ethical, and comprehensive risk assessments.
NAMs encompass a variety of techniques including in silico and in vitro methods , which use cell-based tests to observe biological responses without the use of live animals; computer modeling, which predicts hazardous effects based on virtual simulations and chemical structure analyses; high-throughput screening, which allows rapid testing of thousands of chemicals for toxicological profiles; and omics technologies, which provide detailed molecular profiles that can predict complex biological outcomes. We will look at some examples where early incorporation of NAMs can help identify potentially interesting compounds that save a lot of time and resources downstream allowing a faster regulatory approval process. Special emphasis will be placed on operational workflows that adhere to SSbD principles, such as virtual screening for safer alternatives in product formulations and optimizing these workflows for industrial operations. Furthermore, the session will discuss how SSbD ideas might be integrated into existing regulatory frameworks. We will consider how regulations that recognise and encourage the use of safer and more sustainable may evolve. The talk will demonstrate that such integration is not only feasible, but also necessary for promoting innovation that satisfies future safety and environmental requirements.
At the end, attendees will have a thorough grasp of how NAMs and SSbD may alter the chemical and material sectors by encouraging the development of safer, more sustainable products. The ultimate goal is to encourage a paradigm shift in how industries and regulators approach the development and approval of novel materials, matching technical progress with the need to preserve and sustain human and environmental health.
