Batch: SIL240F011A in stock
1. Description of product
| Protein concentration (mg/mL) | 20 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Volume per vial (μL/vial) | 150 | |||||||||
| Protein content per vial (mg/vial) | 3.0 | |||||||||
| Cap color (depends on the product) | ||||||||||
| SIL000 | SIL210 | SIL220 | SIL230 | SIL250 | SIL260 | SIL270 | SIL240 | SIL200 | ||
| green | red | red | yellow | pink | yellow | red | white | blue | ||
| Phase I dependent activities(Vmax) | ACTIVITY | ENZYME | Substrate (Concentration (µM)) | |||||||
| Phenacetin O-deethylation | CYP1A2 | Phenacetin 200 μM | ||||||||
| Bupropion hydroxylation | CYP2B6 | Bupropion 300 μM | ||||||||
| Amodiaquine N-deethylation | CYP2C8 | Amodiaquin 20 μM | ||||||||
| Diclofenac 4’-hydroxylation | CYP2C9 | Diclofenac 200 μM | ||||||||
| Mephenytoin hydroxylation | CYP2C19 | (S)-Mephenytoin 60 μM | ||||||||
| Dextromethorphan O-demethylation | CYP2D6 | Dextromethorphan 20 μM | ||||||||
| Chlorzoxazone 6-hydroxylation | CYP2E1 | Chlorzoxazone 200 μM | ||||||||
| Testosterone 6β-hydroxylation | CYP3A4 | Testosterone 75 μM | ||||||||
| Nifedipine oxidation | CYP3A4 | Nifedipine 50 μM | ||||||||
2. Product characterisation
Phase I dependent activities (Vmax) (pmol x min-1 x mg-1 protein)
| Activity | Enzyme | Result | % inhibition |
|---|---|---|---|
| Phenacetin O-deethylation | CYP1A2 | 532.0 | 9.0 |
| Coumarin 7-hydroxylation | CYP2A6 | 603.0 | 0.0 |
| Bupropion hydroxylation | CYP2B6 | 145.0 | 44.0 |
| Amodiaquine N-deethylation | CYP2C8 | 731.0 | 0.0 |
| Diclofenac 4’-hydroxylation | CYP2C9 | 839.0 | 0.0 |
| Mephenytoin hydroxylation | CYP2C19 | 23.0 | 0.0 |
| Dextromethorphan O-demethylation | CYP2D6 | 15.0 | 89.0 |
| Chlorzoxazone 6-hydroxylation | CYP2E1 | 3138.0 | 0.0 |
| Testosterone 6β-hydroxylation | CYP3A4 | 584.0 | 10.0 |
| Nifedipine oxidation | CYP3A4 | 405.0 | 23.0 |
| Midazolam 1’-hydroxylation | CYP3A4 | 1307.0 | 39.0 |
3. Conditions of storage and delivery
| Date of manufacture | June 3, 2019 |
|---|---|
| Storage temperature | -80.0 °C |
| Delivery | In dry ice |
| Last control date | September 8, 2019 |
| Expiry date | June 3, 2025 |
| Date of batch release | October 27, 2020 |
