SaferWorldbyDesign: Tier 1 New Approach Method Case Study Analysis Evaluating Organ Toxicities based on Existing Knowledge

The SaferWorldbyDesign platform integrates trusted knowledge, FAIR data resources, and AI-assisted workflows to accelerate the development and application of New Approach Methodologies (NAMs) for chemical safety and Safe and Sustainable by Design (SSbD). In this webinar, we present a Tier 1 case study analysis demonstrating how existing knowledge and evidence can be leveraged to evaluate potential organ toxicities, focusing on the SaferLiver, SaferKidney, and SaferNeuron solutions. By combining structured data, mechanistic insights, and computational models, the workflow enables early identification of risks while reducing reliance on animal testing. The case study illustrates how integrating compound data, method annotations, and mechanistic frameworks such as Adverse Outcome Pathways (AOPs) can support decision-making on safety profiles and guide the prioritization of further testing. The webinar will highlight the importance of transparent, reproducible evidence workflows in enabling regulatory acceptance of NAMs and fostering innovation toward safer products and materials.

Speakers:

Paul Jennings (Vrije Universiteit Amsterdam)

Paul Jennings is lead researcher of the Molecular and Computational Toxicology group. His background is in epithelial and renal biology, in vitro cell culture system development and mechanistic toxicology. Paul hails from Dublin Ireland. He did his BSc and PhD at the University College Dublin. He did research in Innsbruck, Austria working with Prof. Walter Pfaller. In 2009 Paul habilitated in Epithelial Physiology (Venia Docendi). 

Barry Hardy (Edelweiss Connect)

Dr. Barry Hardy is the Chief Executive Officer (CEO) at Edelweiss Connect where he is leading its team supporting the development of new integrating solutions in industrial product design and safety assessment and the translation of research methods to industrial practice. Example recent commercial developments include the creation of the SaferWorldbyDesign platform (https://www.saferworldbydesign.com/), and the development of the SaferSkin (https://saferworldbydesign.com/saferskin/) and EdelweissData products (https://saferworldbydesign.com/edelweissdata/). He is currently leading the development of risk assessment knowledge infrastructure and solutions, including new approach methods, SaferbyDesign, sustainability and next generation risk assessment solutions (https://www.risk-hunt3r.eu).