NextGen Basel 1 - Next Generation Product Design and Risk Assessment
A multistakeholder symposium on the practical application of emerging methods
1 March 2024 - Technology Park Basel, Basel, Switzerland
Goals of the Event
- Share knowledge and best practices on the practical application of new approach methods to product design and risk assessment
- Bring different stakeholders together to support collaboration developing innovation and application opportunities
- Discuss existing and potential case study work promoting sufficient quality of evidence supporting decision-making
- Promote the regulatory acceptance of new forms of scientific evidence in safety assessment
Event Program (follow links for abstracts)
- 8.00 Welcome Coffee
- 8.30 Introduction; SaferWorldbyDesign and NextGen Initiative, Barry Hardy (Edelweiss Connect)
- 8.45 Utilisation of New Approach Methods for Regulatory Applications, Ellen Fritsche (SCAHT)
- 9.05 The ASPA Risk Assessment Workflow Framework, Marcel Leist (University of Konstanz)
- 9.25 Modelling the Blood-Brain-Barrier in vitro, Laura Suter-Dick (FHNW)
- 9.45 Ontologies as the basis for setting up animal-free test batteries: liver toxicity as a case study, Matthieu Vinken (ONTOX and Vrije Universiteit Brussel)
- 10.05 TXG-MAPr tools: gene co-expression network analysis of toxicogenomic data to provide quantitative mode-of-action assessment and prediction of chemical-induced toxicity, Steven J. Kunnen (RISK-HUNT3R and Leiden University)
- 10.25 Coffee Break
- 10.40 Cross-species, multi-omics analyses as a new approach to chemical hazard assessment, Martin Jones (PrecisionTox)
- 11.00 Multi-Organ-on-Chip in Safety and Efficacy Testing: Unraveling Application Scenario Impact on Bioavailability and Effects with Skin, Liver, and Thyroid Models, Beren Atac (TissUse)
- 11.20 Versatility of new approach methods – from early drug discovery to risk stratification exemplified by human liver microtissues, Wolfgang Moritz (InSphero)
- 11.40 NAMS and Practical Industrial Risk Assessment, Nicholas Ball (Dow Chemical)
- Noon Lunch
- 13.00 Challenges and opportunities for the use of modern approaches in pesticide design and risk assessment, Richard Currie (Syngenta)
- 13.20 Use of New Approach Methodologies in Defined Approaches for Skin Sensitization Assessment, Jochen Kuehnl (Beiersdorf)
- 13.40 Challenges and opportunities for the use of new approach methods within environmental risk assessment of cosmetic ingredients, Bruno Campos (Unilever)
- 14.00 Elucidation of hormonal dependencies and associated species specificities of key neurodevelopmental processes to improve EDC risk assessment, Katharina Koch (DNTOX)
- 14.20 3D vessel on-chip system for the assessment of vascular toxicities, Francesca Moretti (Novartis)
- 14.40 Coffee Break
- 15.00 Bridging AI/ML Advancements with Risk Assessment Needs: A Journey Towards Effective Use and Regulatory Acceptance, Serhii Kolesnyk (SCAHT)
- 15.20 Safer and Sustainable by Design – Life Cycle and Sustainability Analysis, Erwan Saouter (Net Zero Impact)
- 15.45 Panel and Audience Discussion
- 16.30 Apéro and Networking
